“We found that 6PGD is an important metabolic branch point in several types of cancer cells. Jing received a PhD degree from E mory University and a Ph. “This is part of the Warburg effect, the distortion of cancer cells’ metabolism,” says team leader Jing Chen, professor of hematology and medical oncology at Emory University School of Medicine and Winship Cancer Institute. Randall Rollins Chair In Oncology at Emory University based in Atlanta, Georgia. Oxidative pentose phosphate pathway regulates AMPK homeostasis by balancing opposing LKB1 and PP2A Chen, Jing Emory University, Atlanta, GA, United States. Researchers have already found 6PGD enzyme activity increased in several types of cancer cells. Jing Chen, PhD, is Professor and Director of the Division of Basic & Translational Science in the Department of Hematology and Medical Oncology at Emory. Parietin appears to inhibit the metabolic enzyme 6PGD (6-phosphogluconate dehydrogenase), which is part of the response that causes rapid cellular growth. Jing Chen Although the oxidative pentose phosphate pathway is important for tumor growth, how 6-phosphogluconate dehydrogenase (6PGD) in this pathway is upregulated in human cancers is unknown. It could also be effective in treating lung and head and neck tumours they say. Parietin, also known as physcion, shows no toxicity to human blood cells, the authors report. The findings are published in the journal Nature Cell Biology. An orange pigment found in lichens and rhubarb called parietin could slow the growth and kill human leukaemia cells, scientists at Winship Cancer Institute of Emory University in Atlanta have discovered.
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